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KMID : 0191120140290010076
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Journal of Korean Medical Science
2014 Volume.29 No. 1 p.76 ~ p.83
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Correction of Anemia with Continuous Erythropoietin Receptor Activator in Korean Patients on Long-Term Hemodialysis
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Oh Ji-Eun
Joo Kwon-Wook
Chin Ho-Jun
Chae Dong-Wan
Kim Sung-Gyun
Kim Soo-Jin
Chung Woo-Kyung
Kim Se-Joong
Huh Woo-Seong
Oh Ha-Young
Choi Bum-Soon
Yang Chul-Woo
Kim Suhng-Gwon
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Abstract
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Continuous erythropoietin receptor activator (CERA) is an erythropoietin with a long-half life. This study investigated the efficacy of CERA for correcting anemia in Korean patients on dialysis. Patients (≥18 yr) who were not receiving any ESAs for more than 8 weeks were randomly assigned to either intravenous CERA once every 2 weeks (n=39) or epoetin beta thrice-weekly (n=41) during a 24-week correction phase. Hemoglobin (Hb) response was defined as increase of Hb by at least 1 g/dL and Hb≥11 g/dL without red blood cell (RBC) transfusion. Median dialysis duration was 1.7 (0.3-20.8) and 1.6 (0.4-13.8) yr in CERA and epoetin beta group, respectively. Hemoglobin response rate of CERA was 79.5% (95% confidence interval [CI], 63.5-90.7). As the lower limit of 95% CI was higher than pre-specified 60% response rate, it can be concluded that CERA corrected anemia (P<0.05). Hb response rate of epoetin beta was 87.8% (95% CI, 73.8-95.9) (P=0.37). Median time to response was 12 weeks in CERA and 10.3 weeks in epoetin beta (P=0.03). It is suggested that once every 2 weeks administration of CERA is effective for correcting anemia in Korean patients on long-term hemodialysis with longer time-to-response than thrice weekly epoetin beta. (ClinicalTrials.gov registry No. NCT00546481)
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KEYWORD
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Anemia Correction, Continuous Erythropoietin Receptor Activator, Kidney Failure, Chronic, Renal Dialysis
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